FABRICATION, OPTIMIZATION AND CHARACTERIZATION OF ANTIPSYCHOTIC DRUG LOADED NANOSTRUCTURED CUBOSOMES AS IN SITU GEL FOR BRAIN TARGETING
Author(s): D. Yookanithya, G. Thanushiya, J. Kannathasan, R. Ranjith
Abstract: In India, every 3 out of 1000 individuals and 1% of world population suffer from schizophrenia. Lurasidone hydrochloride is BCS Class II drug with poor bioavailability of about 9-19% and lacking solubility to show quick response. Atypical antipsychotic agent that function as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist. It is used for the treatment of schizophrenia and bipolar disorder. The major drawback in drug treatment was crossing the blood brain barrier. Drug delivery to the brain is most challenging because of the presence of the blood brain barrier (BBB). Brain targeting through nasal cavity offers safe entry route of drug to brain by restricting BBB as the olfactory receptor cells are in direct contact with the CNS. It constitutes neuronal and extracellular pathways to delivery of therapeutic agent, there is rapid onset of pharmacological action and higher bioavailability of lipophilic drugs. The reason for selecting intranasal insitu drug delivery is because of its large surface area for drug absorption. The drug concentration increases with simultaneous reduction of dose and side effects. The major advantage is that it also avoids first pass metabolism and have rapid onset of action as compared to oral route. insitu delivery system favours the ease and convenience of administration as drops allowing accurate dosing. Cubosomes are nano- structures composed mainly of amphiphilic polar lipid. When this amphiphilic substance dissolved in water with concentration above the critical micelle concentration, it forms micellar aggregations. At higher concentrations, the formed micelles are forced to form cubic structure. Cubosomes may offer over other lipid-based systems, such as liposomes, are the potential to encapsulate a large drug-payload and for sustained release of the entrapped bioactive.
Project ID: DLAP-163
Paper Stream: PHARMACEUTICS
College Name:KMCH COLLEGE OF PHARMACY-Coimbatore
Published Date: 2021-05-01 12:46:06
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